Replacing Animal Models
A Practical Guide to Creating and Using Culture-based Biomimetic AlternativeseBook - 2012
The book is neither political nor polemical: it is technical,illustrating by example how alternatives can be developed and usedand providing useful advice on developing others. After looking atthe reasons for and potential benefits of alternatives to animalexperiments, the book covers a range of methods and examplesemphasising the design considerations that went into each system.The chapters also include 'case studies' that illustrate the waysin which culture models can be used to answer a range of importantbiological questions of direct relevance to human development,physiology, disease and healing.
The thesis of this book is not that all animal experimentationcan be replaced, now or in the near future, by equally effective orsuperior alternatives. Rather, the premise is that there issubstantial opportunity, here and now, to do some common types ofexperiment better in vitro than in vivo, and that doing so willresult in both scientific and ethical gains.