Drug Delivery Strategies for Poorly Water-soluble DrugseBook - 2012
Many newly proposed drugs suffer from poor water solubility,thus presenting major hurdles in the design of suitableformulations for administration to patients. Consequently, thedevelopment of
techniques and materials to overcome these hurdles is a major areaof research in pharmaceutical companies.
Drug Delivery Strategies for Poorly Water-Soluble Drugs providesa comprehensive overview of currently used formulation strategiesfor hydrophobic drugs, including liposome formulation, cyclodextrindrug carriers, solid lipid nanoparticles, polymeric drugencapsulation delivery systems, self-microemulsifying drugdelivery systems, nanocrystals, hydrosol colloidal dispersions,microemulsions, solid dispersions, cosolvent use, dendrimers,polymer- drug conjugates, polymeric micelles, and mesoporous silicananoparticles. For each approach the book discusses the maininstrumentation, operation principles and theoretical background,with a focus on critical
formulation features and clinical studies. Finally, the bookincludes some recent and novel applications, scale-upconsiderations and regulatory issues.
Drug Delivery Strategies for Poorly Water-Soluble Drugs is anessential multidisciplinary guide to this important area of drugformulation for researchers in industry and academia working indrug
delivery, polymers and biomaterials.