Forward-time Population Genetics Simulations
Methods, Implementation, and ApplicationseBook - 2012
The rapid increase of the power of personal computers has led tothe use of serious forward-time simulation programs in geneticstudies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introducessimuPOP, a powerful and flexible new program that can be used tosimulate arbitrary evolutionary processes with unique features likecustomized chromosome types, arbitrary nonrandom mating schemes,virtual subpopulations, information fields, and Pythonoperators.
The book begins with an overview of important concepts andmodels, then goes on to show how simuPOP can simulate a number ofstandard population genetics models--with the goal ofdemonstrating the impact of genetic factors such as mutation,selection, and recombination on standard Wright-Fisher models. Therest of the book is devoted to applications of forward-timesimulations in various research topics.
Forward-Time Population Genetics Simulations includes:
An overview of currently available forward-time simulationmethods, their advantages, and shortcomings
An overview and evaluation of currently available software
A simuPOP tutorial
Applications in population genetics
Applications in genetic epidemiology, statistical genetics, andmapping complex human diseases
The only book of its kind in the field today, Forward-TimePopulation Genetics Simulations will appeal to researchers andstudents of population and statistical genetics.